Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy.
نویسندگان
چکیده
The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.
منابع مشابه
Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 26 شماره
صفحات -
تاریخ انتشار 2011